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| 16 March | | | | Ajax | 2 - 0 | København | B. Traore (23)
K. Dolberg (pen 48) | | |
| | Amsterdam ArenA | |
| | 16 March | | | | Manchester United | 1 - 0 | Rostov | | | Old Trafford | |
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| 16 March | | | | Roma | 2 - 1 | Olympique Lyonnais | K. Strootman (17)
Lucas Tousart (og 60) | | Mouctar Diakhaby (16) |
| | Stadio Olimpico | |
| | 16 March | | | | Borussia M'gladbach | 2 - 2 | Schalke 04 | Andreas Christensen (26)
Mahmoud Dahoud (47) | | L. Goretzka (54)
N. Bentaleb (pen 68) |
| | Stadion im BORUSSIA-PARK | |
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| 16 March | | | | Anderlecht | 1 - 0 | APOEL | | | Stade Constant Vanden Stock | |
| | 16 March | | | | Krasnodar | 0 - 2 | Celta de Vigo | | | | Hugo Mallo (52)
Iago Aspas (80) |
| | Stadion FK Krasnodar | |
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| 16 March | | | | Genk | 1 - 1 | Gent | | Timothy Castagne (20) | | Louis Verstraete (84) |
| | Cristal Arena | |
| | 16 March | | | | Beşiktaş | 4 - 1 | Olympiakos Piraeus | Vincent Paté Aboubakar (10)
Ryan Babel (22)
Ryan Babel (75)
Cenk Tosun (84) | | T. Elyounoussi (31) |
| | Vodafone Arena | |
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| 09 March | | | | Olympique Lyonnais | 4 - 2 | Roma | Mouctar Diakhaby (8)
Corentin Tolisso (47)
Nabil Fekir (74)
Alexandre Lacazette (92) | | Mohamed Salah (20)
F. Fazio (33) |
| | Stade des Lumières | |
| | 09 March | | | | Schalke 04 | 1 - 1 | Borussia M'gladbach | | Guido Burgstaller (25) | | Jonas Hofmann (15) |
| | Veltins-Arena | |
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| 09 March | | | | Gent | 2 - 5 | Genk | Samuel Kalu Ojim (27)
K. Coulibaly (61) | | Ruslan Malinovskiy (21)
Omar Colley (33)
Mbwana Ally Samatta (41)
Jere Uronen (46)
Mbwana Ally Samatta (72) |
| | GHELAMCO-arena | |
| | 09 March | | | | Olympiakos Piraeus | 1 - 1 | Beşiktaş | | E. Cambiasso (36) | | Vincent Paté Aboubakar (53) |
| | Stadio Georgios Karaiskáki | |
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| 09 March | | | | Celta de Vigo | 2 - 1 | Krasnodar | D. Wass (50)
Claudio Beauvue (90) | | Viktor Claesson (56) |
| | Estadio de Balaídos | |
| | 09 March | | | | København | 2 - 1 | Ajax | Rasmus Falk Jensen (1)
Andreas Cornelius (59) | | K. Dolberg (32) |
| | Parken | |
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| 09 March | | | | APOEL | 0 - 1 | Anderlecht | | | Neo GSP | |
| | 09 March | | | | Rostov | 1 - 1 | Manchester United | | Alexander Bukharov (53) | | H. Mkhitaryan (35) |
| | Stadion Olimp 2 | |
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