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| 14 September | | | | Arsenal | 3 - 1 | Köln | S. Kolašinac (49)
A. Sánchez (67)
Bellerín (81) | | J. Córdoba (9) |
| | Emirates Stadium | |
| | 14 September | | | | Vitória Guimarães | 1 - 1 | Salzburg | | Pedrão (25) | | Valon Berisha (45) |
| | Estádio Dom Afonso Henriques | |
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| 14 September | | | | FCSB | 3 - 0 | Viktoria Plzeň | C. Budescu (pen 21)
C. Budescu (44)
D. Alibec (73) | | |
| | Arena Naţională | |
| | 14 September | | | | Crvena Zvezda | 1 - 1 | BATE | | | Stadion Rajko Mitić | |
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| 14 September | | | | Vitesse | 2 - 3 | Lazio | T. Matavž (33)
B. Linssen (57) | | M. Parolo (51)
C. Immobile (67)
A. Murgia (75) |
| | GelreDome | |
| | 14 September | | | | Vardar | 0 - 5 | Zenit | | | | Aleksandr Kokorin (6)
Aleksandr Kokorin (21)
Artem Dzyuba (39)
Branislav Ivanović (66)
E. Rigoni (89) |
| | Telekom Arena | |
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| 14 September | | | | Zulte-Waregem | 1 - 5 | Nice | | A. Leya (46) | | A. Pléa (16)
A. Pléa (20)
Dante (28)
A. Saint-Maximin (69)
M. Balotelli (74) |
| | Regenboogstadion | |
| | 14 September | | | | Hapoel Be'er Sheva | 2 - 1 | Lugano | D. Einbinder (2)
S. Tzedek (pen 60) | | S. Tzedek (og 67) |
| | Yaakov Turner Toto Stadium | |
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| 14 September | | | | Zorya | 0 - 2 | Östersunds FK | | | | Saman Ghoddos (50)
Alhaji Gero (94) |
| | Arena L'viv | |
| | 14 September | | | | Hertha BSC | 0 - 0 | Athletic Club | | Olympiastadion Berlin | |
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| 14 September | | | | Olympique Marseille | 1 - 0 | Konyaspor | | | Stade Vélodrome | |
| | 14 September | | | | Real Sociedad | 4 - 0 | Rosenborg | Diego Llorente (9)
Zurutuza (10)
J. Skjelvik (og 41)
Diego Llorente (77) | | |
| | Estadio Municipal de Anoeta | |
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| 14 September | | | | Dynamo Kyiv | 3 - 1 | Skënderbeu Korçë | S. Sydorchuk (47)
Júnior Moraes (50)
D. Mbokani (pen 65) | | G. Muzaka (39) |
| | NSK Olimpijs'kyj | |
| | 14 September | | | | Rijeka | 1 - 2 | AEK Athens | | J. Elez (29) | | P. Mandalos (16)
L. Christodoulopoulos (62) |
| | Stadion HNK Rijeka | |
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| 14 September | | | | Hoffenheim | 1 - 2 | Sporting Braga | | S. Wagner (24) | | João Carlos (46)
Dyego Sousa (50) |
| | Wirsol Rhein-Neckar-Arena | |
| | 14 September | | | | Austria Wien | 1 - 5 | Milan | | A. Borkovic (47) | | Hakan Çalhanoğlu (7)
André Miguel Valente Silva (10)
André Miguel Valente Silva (20)
André Miguel Valente Silva (56)
Jesús Joaquín Fernández Sáez de la Torre (63) |
| | Ernst-Happel-Stadion | |
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| 14 September | | | | Apollon | 1 - 1 | Olympique Lyonnais | | | Neo GSP | |
| | 14 September | | | | Villarreal | 3 - 1 | Astana | N. Sansone (16)
C. Bakambu (75)
D. Cheryshev (77) | | Y. Logvinenko (68) |
| | Estadio de la Cerámica | |
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| 14 September | | | | København | 0 - 0 | Lokomotiv Moskva | | Telia Parken | |
| | 14 September | | | | Slavia Praha | 1 - 0 | Maccabi Tel Aviv | | | Eden Aréna | |
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| 14 September | | | | İstanbul Başakşehir | 0 - 0 | Ludogorets | | Başakşehir Fatih Terim Stadyumu | |
| | 14 September | | | | Atalanta | 3 - 0 | Everton | A. Masiello (27)
A. Gómez (41)
B. Cristante (44) | | |
| | MAPEI Stadium - Città del Tricolore | |
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| 14 September | | | | Zlín | 0 - 0 | Sheriff | | Andrův stadion | |
| | 14 September | | | | Young Boys | 1 - 1 | Partizan | | C. Fassnacht (14) | | M. Janković (11) |
| | STADE DE SUISSE Wankdorf Bern | |
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