All times CAT (SA, GMT+2)
|
| 21 | Worcester Warriors | v | Northampton Saints | Sixways | 21:45 | |
| 22 | Exeter Chiefs | v | Saracens | Sandy Park | 17:00 | |
| 22 | Leicester Tigers | v | Harlequins | Welford Road | 17:00 | |
| 22 | Sale Sharks | v | Bristol | AJ Bell Stadium | 17:00 | |
| 23 | London Wasps | v | Bath Rugby | Ricoh Arena | 17:00 | |
| 23 | Newcastle Falcons | v | Gloucester Rugby | Kingston Park | 17:00 | |
| 28 | Northampton Saints | v | Exeter Chiefs | Franklin's Gardens | 21:45 | |
| 29 | Saracens | v | Worcester Warriors | Allianz Park | 17:00 | |
| 29 | Gloucester Rugby | v | Sale Sharks | Kingsholm | 17:00 | |
| 29 | Harlequins | v | London Wasps | Twickenham | 18:00 | |
| 30 | Bath Rugby | v | Leicester Tigers | Recreation Ground | 17:00 | |
| 30 | Bristol | v | Newcastle Falcons | Ashton Gate | 17:00 | |
|
| 4 | Sale Sharks | v | Saracens | AJ Bell Stadium | 21:45 | |
| 5 | Exeter Chiefs | v | Bristol | Sandy Park | 17:00 | |
| 5 | Leicester Tigers | v | Gloucester Rugby | Welford Road | 17:00 | |
| 5 | Newcastle Falcons | v | Harlequins | Kingston Park | 17:00 | |
| 5 | Worcester Warriors | v | Bath Rugby | Sixways | 17:00 | |
| 6 | London Wasps | v | Northampton Saints | Ricoh Arena | 17:00 | |
|
| 16 | Bath Rugby | v | Newcastle Falcons | Recreation Ground | 17:00 | |
| 16 | Bristol | v | London Wasps | Ashton Gate | 17:00 | |
| 16 | Gloucester Rugby | v | Exeter Chiefs | Kingsholm | 17:00 | |
| 16 | Harlequins | v | Worcester Warriors | The Stoop | 17:00 | |
| 16 | Northampton Saints | v | Sale Sharks | Franklin's Gardens | 17:00 | |
| 16 | Saracens | v | Leicester Tigers | Allianz Park | 17:00 | |
| 23 | Exeter Chiefs | v | Newcastle Falcons | Sandy Park | 17:00 | |
| 23 | Gloucester Rugby | v | Saracens | Kingsholm | 17:00 | |
| 23 | Harlequins | v | Bristol | The Stoop | 17:00 | |
| 23 | Northampton Saints | v | Bath Rugby | Franklin's Gardens | 17:00 | |
| 23 | London Wasps | v | Sale Sharks | Ricoh Arena | 17:00 | |
| 23 | Worcester Warriors | v | Leicester Tigers | Sixways | 17:00 | |
|
| 2 | Bath Rugby | v | Harlequins | Recreation Ground | 17:00 | |
| 2 | Bristol | v | Gloucester Rugby | Ashton Gate | 17:00 | |
| 2 | Leicester Tigers | v | London Wasps | Welford Road | 17:00 | |
| 2 | Newcastle Falcons | v | Worcester Warriors | Kingston Park | 17:00 | |
| 2 | Sale Sharks | v | Exeter Chiefs | AJ Bell Stadium | 17:00 | |
| 2 | Saracens | v | Northampton Saints | Allianz Park | 17:00 | |
| 9 | Bath Rugby | v | Saracens | Recreation Ground | 17:00 | |
| 9 | Harlequins | v | Gloucester Rugby | The Stoop | 17:00 | |
| 9 | Northampton Saints | v | Bristol | Franklin's Gardens | 17:00 | |
| 9 | Sale Sharks | v | Leicester Tigers | AJ Bell Stadium | 17:00 | |
| 9 | London Wasps | v | Newcastle Falcons | Ricoh Arena | 17:00 | |
| 9 | Worcester Warriors | v | Exeter Chiefs | Sixways | 17:00 | |
| 23 | Bristol | v | Worcester Warriors | Ashton Gate | 17:00 | |
| 23 | Exeter Chiefs | v | Bath Rugby | Sandy Park | 17:00 | |
| 23 | Gloucester Rugby | v | London Wasps | Kingsholm | 17:00 | |
| 23 | Leicester Tigers | v | Northampton Saints | Welford Road | 17:00 | |
| 23 | Newcastle Falcons | v | Sale Sharks | Kingston Park | 17:00 | |
| 23 | Saracens | v | Harlequins | Allianz Park | 17:00 | |
|
| 6 | Bath Rugby | v | Bristol | Twickenham | 16:00 | |
| 6 | Leicester Tigers | v | Exeter Chiefs | Welford Road | 16:00 | |
| 6 | Northampton Saints | v | Gloucester Rugby | Franklin's Gardens | 16:00 | |
| 6 | Sale Sharks | v | Harlequins | AJ Bell Stadium | 16:00 | |
| 6 | Saracens | v | Newcastle Falcons | Allianz Park | 16:00 | |
| 6 | London Wasps | v | Worcester Warriors | Ricoh Arena | 16:00 | |
| 13 | Bristol | v | Saracens | Ashton Gate | 16:00 | |
| 13 | Exeter Chiefs | v | London Wasps | Sandy Park | 16:00 | |
| 13 | Gloucester Rugby | v | Bath Rugby | Kingsholm | 16:00 | |
| 13 | Harlequins | v | Northampton Saints | The Stoop | 16:00 | |
| 13 | Newcastle Falcons | v | Leicester Tigers | Kingston Park | 16:00 | |
| 13 | Worcester Warriors | v | Sale Sharks | Sixways | 16:00 | |
| 27 | Exeter Chiefs | v | Harlequins | Sandy Park | 16:00 | |
| 27 | Leicester Tigers | v | Bristol | Welford Road | 16:00 | |
| 27 | Newcastle Falcons | v | Northampton Saints | Kingston Park | 16:00 | |
| 27 | Sale Sharks | v | Bath Rugby | AJ Bell Stadium | 16:00 | |
| 27 | London Wasps | v | Saracens | Ricoh Arena | 16:00 | |
| 27 | Worcester Warriors | v | Gloucester Rugby | Sixways | 16:00 | |
|
| 4 | Bath Rugby | v | London Wasps | Recreation Ground | 16:00 | |
| 4 | Bristol | v | Sale Sharks | Ashton Gate | 16:00 | |
| 4 | Gloucester Rugby | v | Newcastle Falcons | Kingsholm | 16:00 | |
| 4 | Harlequins | v | Leicester Tigers | The Stoop | 16:00 | |
| 4 | Northampton Saints | v | Worcester Warriors | Franklin's Gardens | 16:00 | |
| 4 | Saracens | v | Exeter Chiefs | Allianz Park | 16:00 | |
| 18 | Exeter Chiefs | v | Northampton Saints | Sandy Park | 16:00 | |
| 18 | Leicester Tigers | v | Bath Rugby | Welford Road | 16:00 | |
| 18 | Newcastle Falcons | v | Bristol | Kingston Park | 16:00 | |
| 18 | Sale Sharks | v | Gloucester Rugby | AJ Bell Stadium | 16:00 | |
| 18 | London Wasps | v | Harlequins | Ricoh Arena | 16:00 | |
| 18 | Worcester Warriors | v | Saracens | Sixways | 16:00 | |
| 24 | TBC | v | TBC | | 16:00 | |
| 25 | TBC | v | TBC | | 16:00 | |
