Matchday one of the 2025/26 CAF Confederation Cup group stage will see Zamalek, Kaizer Chiefs and Wydad Athletic Club targeting victories in their opening games.

Two-time winners Zamalek of Egypt will be confident of starting their Group D campaign with an emphatic victory when they host Zambian club Zesco United at the Cairo International Stadium in Cairo on Saturday.

Zamalek's North African rivals, Wydad of Morocco, are also the clear favourites as they prepare to welcome group stage debutants, Nairobi United of Kenya, at the Stade Mohammed V in Casablanca in a Group B clash.

South African giants Chiefs, on the other hand, will be on the road as they are scheduled to travel to the Cairo International Stadium in Cairo, where they are expected to lock horns with Egyptian outfit Al Masry in a Group D encounter.

Group D heat incoming. Who’s walking away on top? 🧐#TotalEnergiesCAFCC pic.twitter.com/zbKpM6g0Eg

— TotalEnergies CAFCL & CAFCC 🏆 (@CAFCLCC) November 10, 2025

The first Confederation Cup match of the weekend will be played on Saturday, with Algerian side CR Belouizdad set to face Tanzanian side Singida Black Stars in a Group C match at the Nelson Mandela Stadium in Algiers.

Seven matches are scheduled to be played on Sunday with Singida's Tanzanian rivals, Azam, making a short trip to neighbouring DR Congo, where they are expected to battle it out with AS Maniema Union in a Group B encounter at the Stade des Martyrs in Kinshasa.

Who’s got the edge in this Group B battle? 🤯#TotalEnergiesCAFCC pic.twitter.com/oJDyZ6sC2r

— TotalEnergies CAFCL & CAFCC 🏆 (@CAFCLCC) November 8, 2025

Group A will see Algerian Cup champions USM Alger take on Ivorian side San Pedro at the Stade du 5 Juillet in Algiers, while Malian giants Djoliba AC are poised to welcome Morocco's Olympic Club Safi at the Stade du 26 Mars in Bamako.

Who’s coming out on top of this Group A showdown? 😮‍💨#TotalEnergiesCAFCC pic.twitter.com/MXSZe0f9va

— TotalEnergies CAFCL & CAFCC 🏆 (@CAFCLCC) November 7, 2025

Lastly, last season's semifinalists, Stellenbosch FC of South Africa, will play host to Congo-Brazzaville outfit AS Otoho at the 2010 FIFA World Cup venue, New Peter Mokaba Stadium, in a Group C encounter.

It’s all to play for in Group C, who do you see finishing top? 🤔#TotalEnergiesCAFCC pic.twitter.com/fZ79dtUKha

— TotalEnergies CAFCL & CAFCC 🏆 (@CAFCLCC) November 9, 2025

Full fixtures

Saturday, November 22

9pm - CR Belouizdad v Singida Black Stars

Sunday, November 23

3pm - AS Maniema Union v Azam FC

3pm - Stellenbosch FC v AS Otoho

6pm - Al Masry v Kaizer Chiefs

6pm - Djoliba v Olympic Club Saf

9pm - USM Alger v FC San Pedro

9pm - Wydad AC v Nairobi United

9pm - Zamalek v Zesco United