The Lions have been forced to include a new lock pairing for their Vodacom United Rugby Championship derby game against the Hollywoodbets Sharks in Durban on Saturday.
After winning the previous derby game, the Lions will be confident that they can pull off the double against a resurgent Sharks side.
Etienne Oosthuizen and Ruben Schoeman will be the lock pairing for the match after Darrien Landsberg and Reinhard Nothnagel both missed out on the match with varying injuries.
Landsberg suffered a shoulder injury in the loss against the Stormers while Nothnagel is still on concussion protocols.
Angelo Davids returns to the side on the wing for Eduan Keyter, another player undergoing concussion protocols, while Eddie Davids starts at loosehead prop after an injury to SJ Kotze.
World Junior Player of the year Haashim Pead has been brought onto the bench as has impressive jackler Renzo du Plessis, to give the Lions a bit of punch in the second half.
The Lions also have four Springboks in their side - Asenathi Ntlabakanye, Ruan Venter, Morne van den Berg and Quan Horn.
LIONS: Quan Horn; Kelly Mpeku, Erich Cronje, Bronson Mills, Angelo Davids; Chris Smith, Morne van den Berg; Francke Horn (captain), Ruan Venter, Jarod Cairns, Ruben Schoeman, Etienne Oosthuizen, Asenathi Ntlabakanye, PJ Botha, Eddie Davids.
Replacements: Morne Brandon, RF Schoeman, Conraad van Vuuren, Ruan Delport, Siba Qoma, Renzo du Plessis, Haashim Pead, Richard Kriel.