Henry Slade has been left out of England's squad for the Autumn Nations Series in a surprise decision by Eddie Jones.
Slade missed the tour to Australia in July because of shoulder surgery but has been in action for Exeter since the start of the season.
Will Joseph, Guy Porter, Manu Tuilagi and Owen Farrell are the recognised centres named in the 36-man group that will face Argentina, Japan, New Zealand and South Africa at Twickenham next month.
Prop Kyle Sinckler is also back, having sat out the 2-1 series victory over the Wallabies because of a back issue.
Harlequins' uncapped wing Cadan Murley features in a senior England squad for the first time but experienced players Elliot Daly and Joe Marler miss out.
"This is a very strong, vibrant squad and a number of good players have been left out," said England coach Jones on Monday. "We are pleased with the depth and the strength of the squad.
"The autumn internationals will be like a mini World Cup for us, starting with two tough games against Argentina and Japan which mirrors our pool fixtures at next year's tournament.
"Then we'll have knock-out type games against New Zealand and South Africa – all four games will be great tests for us."
England squad:
Forwards: Alex Coles (Northampton), Luke Cowan-Dickie (Exeter), Tom Curry (Sale), Ellis Genge (Bristol), Joe Heyes (Leicester), Jonny Hill (Sale), Maro Itoje (Saracens), Courtney Lawes (Northampton), Lewis Ludlam (Northampton), George McGuigan (Newcastle), Val Rapava Ruskin (Gloucester), David Ribbans (Northampton), Bevan Rodd (Sale), Sam Simmonds (Exeter), Kyle Sinckler (Bristol), Jack Singleton (Gloucester), Hugh Tizard (Saracens), Billy Vunipola (Saracens), Mako Vunipola (Saracens) Jack Willis (Wasps)
Backs: Henry Arundell (London Irish), Joe Cokanasiga (Bath), Owen Farrell (Saracens), George Furbank (Northampton), Will Joseph (London Irish), Max Malins (Saracens), Jonny May (Gloucester), Cadan Murley (Harlequins), Jack Nowell (Exeter), Guy Porter (Leicester), Raffi Quirke (Sale), Marcus Smith (Harlequins), Freddie Steward (Leicester), Manu Tuilagi (Sale), Jack van Poortvliet (Leicester), Ben Youngs (Leicester)
