England hooker Jamie George and backs Ollie Lawrence and Tom Roebuck have all been ruled out of Sunday's match against Argentina at Twickenham after suffering injuries last weekend in the win over New Zealand.
The trio were missing from the 35-man squad named on Tuesday.
George and centre Lawrence both picked up hamstring injuries in the 33-19 triumph against the All Blacks, while wing Roebuck suffered a foot injury.
Steve Borthwick's depleted England will be bidding for an 11th straight win when they take on Argentina.
The Pumas are targeting a third victory of their autumn tour after crushing Wales earlier this month and then edging a dramatic game against Scotland on Sunday 33-24.
England were already without lock Ollie Chessum and wing Tommy Freeman due to injuries.
